Explore the concept clearance for Multi-Omics for Health and Disease in this 48-minute presentation from the 95th annual meeting of the National Advisory Council for Human Genome Research. Delve into the definition and integration of multi-omics, examining its potential to detect molecular profiles and develop generalizable methods. Learn about the proposed Multi-Omics Consortium structure, including disease study sites, 'omics production centers, and data coordination centers. Discover how this initiative aims to create an interoperable multi-dimensional dataset while addressing diversity in genomic research. Gain insights into the program's purpose, budget, and relationship to ongoing activities in the field of genomic medicine.