Explore a JavaScript framework for computational simulations in this JSConfUS 2013 talk. Learn about the development of a JavaScript and HTML5 version of the educational physics simulation Molecular Workbench, funded by the Google Foundation. Discover how this framework enables the creation of explorable scientific simulations that run in browsers, leveraging JavaScript's speed and the web's ubiquity. Gain insights into performance optimization and extensibility considerations for this new form of web application. Examine various models including two-dimensional molecules, temperature, protein folding, DNA transcription and translation, and quantum collision. Dive into the framework's architecture, covering topics such as GitHub integration, MVC pattern implementation, invalidation techniques, time handling, and fluid dynamics simulation.