Explore the intricacies of binary data handling in JavaScript during this 45-minute JSConf talk. Dive into HTML5's binary APIs, file uploads, client-side caching, and local image display. Learn to decode binary data, process images, and manage file uploads and downloads. Discover practical applications through examples of local image handling and text file reading. Gain insights into DataView, Blob creation, and audio synthesis. Examine the use of sandboxed files, Blobs as messages, and their integration with databases. Master the essentials of working with bytes and blobs to enhance your JavaScript development skills.