Explore the intersection of predictive analytics and machine learning in high-stakes industries through this 30-minute conference talk. Delve into critical decision-making processes, risk assessment, and uncertainty management as applied in NASA's space missions and Hollywood's talent acquisition. Learn how Monte Carlo Analysis and other advanced techniques are utilized to optimize complex systems and enhance business outcomes. Gain insights into real-world applications of machine learning, from space launch systems to sports analytics, and discover how explicit uncertainty can be leveraged for better decision-making in various fields.