Embark on a journey through the galaxy of Command-Line Interfaces (CLIs) in Python with this engaging PyCon US talk. Explore the history and evolution of CLIs, from their origins in teletype machines to modern implementations. Discover the anatomy of CLIs, including signals, control characters, and escape sequences. Learn about essential Python packages for creating robust command-line applications. Examine popular CLIs and gain hands-on experience by building your own using Click. Master the art of packaging and publishing your CLI on PyPI. Dive into advanced topics such as progress bars, colored text, user prompts, and testing. By the end of this 25-minute presentation, equip yourself with the knowledge to create user-friendly and efficient command-line tools in Python.