Explore the intricacies of malware detection and signature-based security in this conference talk from GrrCon 2018. Delve into the history of security, the evolution of malware, and the challenges of signature-based detection methods. Learn about bypass techniques, modern malware trends, and the impact on various sectors, including healthcare. Examine different approaches to malware detection, including monitoring processes, machine learning, and statistical models. Discover the limitations of signature-based detection and explore alternative methods such as sandboxing, threat modeling, and behavioral analysis. Gain insights into customizing sandboxes, identifying key indicators like file drops and process IDs, and understanding the role of web filtering and Microsoft's security toolkit. Conclude with a discussion on the future of malware detection and participate in a Q&A session to further enhance your understanding of this critical cybersecurity topic.