Explore a groundbreaking conference talk from OSDI '20 that introduces Assise, a distributed file system leveraging non-volatile memory (NVM) colocation to revolutionize performance and availability. Delve into how Assise challenges traditional remote storage models by colocating computation with persistent memory modules (PMMs), offering applications significantly enhanced IO performance, rapid failover, and robust consistency. Discover the innovative persistent, replicated coherence protocol that manages client-local PMM as a linearizable and crash-recoverable cache. Learn how Assise maximizes locality for file IO operations and minimizes coherence overhead through operation-granularity consistency maintenance. Examine comparative performance results against systems like Ceph/BlueStore, NFS, and Octopus, showcasing Assise's impressive improvements in write latency, throughput, fail-over time, and scalability across various cloud applications and benchmarks.