Explore depression from a neurological perspective in this 19-minute TEDx talk by Dr. Helen Mayberg. Gain insights into brain circuit mapping and first-person experiences to develop a deeper, empathetic understanding of negative moods. Learn how Dr. Mayberg's multi-disciplinary research team integrates cutting-edge imaging strategies, quantitative behavioral and psychophysiological metrics, and experimental treatment trials to define brain-based biomarkers for optimizing depression treatment. Discover the groundbreaking work on subcallosal cingulate deep brain stimulation for treatment-resistant depression and its ongoing refinement. Delve into the network mechanisms mediating antidepressant effects and the potential for personalized treatment approaches based on neurological findings.