Explore the evolution and future of fundamental physics in this thought-provoking lecture by Nobel laureate Steven Weinberg. Delve into the growth of physics from its small origins to the era of Big Science, examining the motivations behind this expansion and its significant outcomes. Analyze the challenges faced by large-scale scientific endeavors, particularly in light of reduced funding for basic research. Gain insights into the importance of continued investment in scientific advancement and the potential consequences of scaling back Big Science initiatives. Discover the technological spin-offs of scientific research and the unique challenges faced by different scientific disciplines. Reflect on the DIY nature of scientists and the exciting developments in contemporary science. Consider the competition for resources between various scientific projects and its impact on the field's progress.