Delve into the neuroscience of addiction in this 87-minute World Science Festival panel discussion featuring psychiatrist Nora Volkow, chemist Kim Janda, and neuroscientists Eric Nestler and Amir Levine. Explore how addiction alters brain reward pathways, the current state of addiction in the U.S., and the latest research on breaking addictive cycles. Discover insights on memory formation under the influence, the impact of addiction on the brain, potential predictors of addiction, and the controversial topic of gateway drugs. Learn about cutting-edge approaches like heroin vaccines, discuss the role of big pharma in addiction treatment, and examine the social stigma surrounding addiction. Gain a comprehensive understanding of the complexities of addiction and the ongoing efforts to combat this pervasive issue through scientific advancements and social awareness.