Explore a comprehensive conference talk from LISA16 that delves into the principles of Site Reliability Engineering (SRE) and their applicability to organizations of all sizes. Discover how SRE practices, often associated with large-scale systems engineering, can be effectively implemented in both small startups and major corporations like Google. Learn about key SRE concepts, including load testing, application state management, monitoring, dependency management, sharding, and distributed applications. Gain insights into common objections to SRE implementation and understand the trade-offs involved. Examine real-world examples and case studies that illustrate the practical application of SRE principles across various scenarios. Uncover little-known facts about SRE and explore arguments for and against microservices architecture in the context of reliability engineering.