Explore the rapidly expanding field of β-lactam/β-lactamase inhibitor combinations in this 47-minute podcast from the American Society for Microbiology. Delve into the evolution of β-lactam/β-lactamase inhibitor discovery, examine the current state-of-the-art development of novel combinations, and analyze their present and future clinical applications against major antimicrobial-resistant pathogens. Learn about the history of betalactamase inhibitors, their mechanisms of action, and strategic deployment. Discuss the management of these drugs, with a focus on their effectiveness against Pseudomonas. Gain valuable insights into this promising short-term strategy against recalcitrant Gram-negative pathogens.