Explore the critical issue of B-lactamase nomenclature in this 42-minute video from the American Society for Microbiology. Delve into the inconsistencies in naming B-lactamase variants and the confusion it has caused in scientific literature. Learn about the exponential growth in new B-lactamase genes due to whole genome sequencing availability. Discover the outcomes of a virtual meeting of international B-lactamase experts aimed at developing a consensus for naming naturally-occurring B-lactamase genes. Gain insights from leading experts Patricia Bradford, Karen Bush, and Robert Bonomo as they discuss guidelines for publishing new alleles and B-lactamases, address future consensus needs, and propose solutions to standardize nomenclature. Dedicated to the memory of George A. Jacoby, a pioneer in B-lactamase research, this video offers valuable information for microbiologists, researchers, and anyone interested in antimicrobial resistance.