Dive into an in-depth exploration of antibiotic development through this comprehensive workshop from the 2017 ASM/ESCMID Conference on Drug Development to Meet the Challenge of Antimicrobial Resistance. Learn about the crucial aspects of identifying good hits and leads, and understand the importance and process of writing a Target Product Profile (TPP). Gain insights from expert discussants including Lynn Silver, Tom Dougherty, John Tomayko, and Sherman T. Waddell as they cover topics such as discovery strategies, hit generation, mechanism of action, pharmacology evaluation, screening methods, and library collections. Explore the challenges of data interpretation, false positives, and triage processes in drug development. Delve into structure-activity relationships, optimization techniques, and the importance of drug-like properties. Examine the Rule of Five, Lipinski space, and the differences between Gram-positive and Gram-negative antibacterials. Analyze real-world examples and learn about key parameters in optimization, pharmacokinetics, therapeutic index, and medicinal chemistry principles essential for successful antibiotic development. Read more