Explore the intricate cell biology of invasive growth in the rice blast fungus Magnaporthe oryzae through this comprehensive plenary lecture delivered by Nick Talbot at the 2019 SEB Annual Meeting in Seville. Delve into the disease symptoms, including neck blast, rice blast, and wheat blast, while examining the cellular mechanisms of infection. Investigate effectors, membrane integrity, and swelling constriction through transmission electron microscopy. Gain insights into the PMK1 pathway, chemical genetic approaches, and pathogen perception. Conclude with a summary of findings, acknowledgment of collaborators, and recognition of awards in this hour-long presentation from The Sainsbury Laboratory, UK.