Explore the complex, persistent problems affecting health and medicine in America through this TEDMED Great Challenges talk on social determinants of health. Delve into the multifaceted issues that impact millions of lives and extend beyond medical causes to include social, economic, and psychological factors. Examine the interconnected nature of these challenges and their far-reaching effects across various sectors of society. Gain insights from a diverse panel of experts as they discuss topics such as academic health centers, aligning economic incentives, and innovative approaches like Health Leads. Discover personal stories that illustrate the impact of chronic debilitating diseases and explore potential solutions. Learn about measures of success, healthcare workforce challenges, community engagement, and innovations in care access. Understand the importance of sustainable prevention strategies in addressing these complex health issues.