Explore the fascinating world of particle physics in this 57-minute conference talk from the World Science Festival. Delve into the mysteries of neutrinos, matter, and antimatter as leading particle physicists discuss their quest to detect an incredibly rare neutrino event that could explain the existence of our matter-filled universe. Learn about the discovery of antimatter, Majorana particles, and the experiments designed to detect neutrinoless double-beta decay. Discover the IceCube Neutrino Observatory, various types of neutrinos, and the challenges of running experiments underground. Gain insights into the potential implications of detecting or failing to detect neutrinoless double-beta decay, and explore the current limits of detector technology. Engage with expert discussions on the annihilation of matter and antimatter, and predictions for future discoveries in this cutting-edge field of scientific research.