Explore innovative approaches to enhance k-means clustering through simple iterative optimization techniques in this 40-minute conference talk from the Computational Genomics Summer Institute (CGSI) 2024. Delve into Jason Xu's research on improving the popular clustering algorithm, drawing insights from related papers on power k-means clustering, sparse k-means clustering via feature ranking, and entropy-weighted power k-means clustering. Gain valuable knowledge on advanced clustering methods and their applications in computational genomics and machine learning.