Explore a comprehensive lecture on liberating adult ICU patients from mechanical ventilation presented by Dr. Eddy Fan. Delve into current evidence and clinical practice guidelines, including the potential role of non-invasive respiratory support in facilitating liberation and mitigating post-extubation failure. Learn about the risks associated with mechanical ventilation, failure of spontaneous breathing, and various weaning and discontinuation practices. Examine key topics such as ACCP/SCCM/AARC guidelines, airway protection, spontaneous breathing trials, sedation protocols, extubation to NIV, early mobilization, ventilator liberation protocols, cuff leak tests, and the use of systemic steroids. Investigate the comparison between nasal high-flow and Venturi mask oxygen therapy after extubation, and consider the optimal rate of failed extubation in critical care settings.